PAMAM dendrimers as quantized building blocks for novel nanostructures

PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures.

The desire to synthesize soft supramolecular structures with size scales similar to biological systems has led to work in assembly of polymeric nanomaterials. Recent advances in the isolation of generationally homogenous poly(amidoamine) (PAMAM) dendrimer enables their use as quantized building blocks. Here, we report their assembly into precise nanoclusters. In this work, click-functional liga...

Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Blocks for Nanoscale Synthetic Organic Chemistry

Diamond fragments as building blocks of functional nanostructures

Using density functional theory, we investigate the equilibrium structure, stability, and electronic properties of nanostructured, hydrogen-terminated diamond fragments. The equilibrium atomic arrangement and electronic structure of these nanostructures turn out to be very similar to bulk diamond. We find that such diamondoids may enter spontaneously into carbon nanotubes. Polymerization inside...

Structure of PAMAM Dendrimers: Generations

The structure and dynamics of poly(amido amide) (PAMAM) dendrimers have been of great interest both scientifically and industrially, but such important features as the distributions of atoms, channels, and strain inside these molecules remain unresolved. This paper reports results from systematic investigations of the atomistic structure of ethylenediamine (EDA) cored PAMAM dendrimer up through...

Cationic PAMAM Dendrimers as Pore-Blocking Binary Toxin Inhibitors

Dendrimers are unique highly branched macromolecules with numerous groundbreaking biomedical applications under development. Here we identified poly(amido amine) (PAMAM) dendrimers as novel blockers for the pore-forming B components of the binary anthrax toxin (PA63) and Clostridium botulinum C2 toxin (C2IIa). These pores are essential for delivery of the enzymatic A components of the internali...